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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| ABZ4485-100 | 2 weeks | 100 µL | $499.00 |
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| ABZ4485-20 | 2 weeks | 20 µL | $149.00 |
Product Overview | |
| Name | Phospho-KCNQ2/3/4/5 (Thr217/Thr246/Thr223/Thr251) Rabbit pAb |
|---|---|
| Accession (Primary) | O43526 |
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Species Reactivity | |
| Reacts With | Human, Mouse, Rat |
| Buffer System | |
| Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. | |
| Storage | |
| Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. | |
| Recommended Dilution | |
| WB-1:500-1:2000; IHC-1:100-1:300; IF-1:50-1:200; ELISA-1:20000 | |
| Purification | |
| Affinity Chromatography | |
| Conjugation | |
| Unconjugated | |
| Modification | |
| Phosphorylated | |
| Form | |
| Liquid | |
| Background | |
| The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. | |
Target Information: ( O43526 ) | |
| Name | KCNQ2/KCNQ3/KCNQ4/KCNQ5 |
| Gene ID | 3785/3786/9132/56479 |
| Other Names | |
| KQT-like 2; KCNQ2; KQT-like 4; KCNQ5 | |
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ADMEbio Team
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