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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP0001-2 | 2 µg | $120.00 |
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| RCP0001-10 | 10 µg | $290.00 | ||||
| RCP0001-1 | 1 mg | $8,320.00 |
Product Overview | |
| Name | A2LD1 Human |
|---|---|
| Description | |
| AIG2-Like Domain 1 Human Recombinant | |
| Accession (Primary) | Q9BVM4 |
| Synonyms | |
| Alpha-2-macroglobulin, Alpha-2-M, A2M, CPAMD5, FWP007, S863-7, alpha 2M, DKFZp779B086. | |
| Introduction | |
| Alpha-2 Macroglobulin is a serine proteases inhibitor, which inhibits coagulation by inactivating thrombin and Kallikrein, it inhibits fibrinolysis by inactivating plasmin and involved in transport. Alpha-2-Macroglobulin is a large plasma protein, which is produced by the liver, it’s composed of 4 identical subunits bound together by -S-S- bonds. A2M is able to inactivate many kinds of proteinases (including serine-, cysteine-, aspartic- and metalloproteinases). A2M has a 35 amino acid "bait" region in its structure. Proteinases bind and cleave the “bait” region become bound to A2M. Macrophage receptors recognize the proteinase-A2M complex and clear it from the system. A2M binds to and removes MMP-2 and MMP-9 (active forms of the gelatinase) from the circulation using scavenger receptors on the phagocytes. The levels of Alpha-2-macroglobulin are increased in nephrotic syndrome which is a condition where the kidneys start to leak out some of the smaller blood proteins. Due to its large size, A2-macroglobulin is retained in the bloodstream. Increased production of all proteins causes A2-macroglobulin concentration to increase. Chronic renal failure might lead to amyloid by alpha-2-macroglobulin. A2M is raised in cirrhosis, pregnancy and diabetes. | |
| Source | |
| Human Plasma. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Lyophilized from a concentrated solution containing 5mM potassium phosphate buffer, pH 6.5 and 1:1 ratio (w/w) of Glycine. | |
| Stability | |
| Lyophilized A2M protein although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution and filter sterilization A2M can be stored at 4°C for up to 4 weeks. For long term storage and more diluted solutions it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0%. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized A2M in sterile 18MΩ-cm H 2 O. | |
| Human Virus Test | |
| Serum from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV and HBV. | |
| Precautions | |
| A2LD1 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q9BVM4 ) | |
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ADMEbio Team
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