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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| NTP0001-200 | 200 µg | $200.00 |
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| NTP0001-1 | 1 mg | $660.00 | ||||
| NTP0001-10 | 10 mg | $4,400.00 |
Product Overview | |
| Name | A2M Human |
|---|---|
| Description | |
| Macroglobulin Alpha-2 Human | |
| Accession (Primary) | P01023 |
| Synonyms | |
| Alpha-actinin-1, Alpha-actinin cytoskeletal isoform, Non-muscle alpha-actinin-1, F-actin cross-linking protein, ACTN1. | |
| Introduction | |
| ACTN1 encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. | |
| Source | |
| Chicken Gizzard. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The protein was lyophilized from a 1mg/ml solution containing 10mM Tris acetate buffer pH 7.6, 0.1mM EDTA, 2mM DTT, and 20mM NaCl. | |
| Stability | |
| Lyophilized a-Actinin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution a-Actinin should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by analysis by SDS-PAGE. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized a-Actinin in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Applications | |
| Protein standard in 1D and 2D SDS gelelectrophoresis Immunoassays Immunization. | |
| Precautions | |
| A2M Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P01023 ) | |
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ADMEbio Team
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