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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP0003-5 | 5 µg | $120.00 |
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| RCP0003-20 | 20 µg | $290.00 | ||||
| RCP0003-1 | 1 mg | $4,320.00 |
Product Overview | |
| Name | AAMDC Human |
|---|---|
| Description | |
| Adipogenesis Associated, Mth938 Domain Containing Human Recombinant | |
| Accession (Primary) | Q9H7C9 |
| Synonyms | |
| Alanyl-tRNA synthetase cytoplasmic, EC 6.1.1.7, Alanine-tRNA ligase, AlaRS, Renal carcinoma antigen NY-REN-42, PL-12, AARS. | |
| Introduction | |
| Alanyl-tRNA synthetase is a member of the aminoacyl-tRNA synthetase family, key enzymes of protein biosynthesis which charge tRNA molecules with the respective amino acids. This 108 kDa protein is an autoantigen recognized by PL-12 antibodies which occur in a subset of patients with polymyositis and dermatomyositis. Preliminary data suggest that epitope spreading occurs in the autoimmune PL-12 response such that even antibodies to an isolated alanyl-tRNA molecule can develop. | |
| Source | |
| Sf9 insect cells. | |
| Physical Appearance | |
| Sterile Filtered clear solution. | |
| Formulation | |
| AARS is supplied in 20mM HEPES buffer pH-8, 250mM sodium chloride, and 20% glycerol. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. | |
| Purity | |
| AARS purity is greater than 95% as determined by SDS-PAGE. | |
| Immunological functions | |
| 1. Binds IgG-type human auto-antibodies. 2. Standard ELISA test (checker-board analysis of positive/negative sampels ). | |
| Coating concentration | |
| 0.3-0.8 µg/ml (depending on the type of ELISA plate and coating buffer).Suitable for labeling of functional groups. | |
| Precautions | |
| AAMDC Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q9H7C9 ) | |
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ADMEbio Team
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ADMEbio Team
