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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| ABM0048-5 | 7 days | 5 µg | $120.00 |
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| ABM0048-20 | 7 days | 20 µg | $290.00 | |||
| ABM0048-100 | 7 days | 100 µg | $720.00 |
Product Overview | |
| Name | B2M Antibody |
|---|---|
| Description | |
| Beta 2 Microglobulin, Mouse Anti Human | |
| Synonyms | |
| Beta-2-microglobulin, B2M. | |
| Introduction | |
| Beta 2 microglobulin is an 11 kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2 microglobulin associates with class I-like molecules such as CD1 and Qa as well as with the alpha chain of MHC class I molecules. Very limited amounts of MHC class I molecules can be found on the surface in the absence of Beta 2 microglobulin. CD8 T cells cannot develop in the absence of MHC class I. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinaemia, renal failure, or kidney transplants. Human Beta 2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumors and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy). Beta-2 microglobulin levels might also be elevated in multiple myeloma and lymphoma cases. Dialysis-related amyloidosis develops after a long-term hemodialysis, it can aggregate into amyloid fibers that deposit in joint spaces. | |
| Source | |
| Human urine from patients with tubular proteinuria. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Lyophilized from 0.02M NH4HCO3 pH-7.2, 0.15M NaCl, 1mM NaCl, 1mM EDTA, 2% mannitol and 0.09% NaN3. | |
| Stability | |
| Human B2M although stable at room temperature for 3 weeks, should be stored between 2-8°C. | |
| Purity | |
| Greater than 95%. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized HuB2M in water at 1mg/ml. | |
| Human Virus Test | |
| Starting material tested and found negative for HIV I & II antibodies, Hepatitis B surface antigen and Hepatitis C antibodies. | |
| Precautions | |
| B2M Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Thank you,
ADMEbio Team
ADMEbio welcomes feedback from our customers.
Thank you,
ADMEbio Team
