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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| ABM0688-500 | 7 days | 500 µg | $700.00 |
Select product before adding to cart
|
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| ABM0688-1 | 7 days | 1 mg | $1,000.00 |
Product Overview | |
| Name | Vimentin Antibody, Biotin |
|---|---|
| Description | |
| Vimentin, Mouse Anti Human Antibody, Biotin | |
| Immunogen | |
| Purified Human Vimentin. | |
| Introduction | |
| Vimentin expression in human malignant glioma cells depends on cellular density, algorithms of drug delivery and chemo/radio treatment. Vimentin and detyrosinated microtubules provide structural support for the extensive microtentacles observed in detached tumor cells and a mechanism to promote successful metastatic spread. Primary colorectal carcinomas display aberrant expression of vimentin, and have activated Notch and TGFbeta signaling pathways. Vimentin is a strong arterial substrate for transglutaminases. Transglutaminase-mediated vimentin dimerization results in a novel unifying pathway by which vasodilatory and remodeling responses may be regulated. Ablation of vimentin expression inhibits migration and invasion of colon and breast cancer cell lines. | |
| Formulation | |
| 1mg/ml in PBS (after reconstitution). | |
| Solubility | |
| Reconstitute with H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. | |
| Applications | |
| Immunohistochemistry. | |
| Type | |
| Mouse Anti Human Monoclonal Antibody. | |
| Clone | |
| hVimentin. | |
| Ig Subclass | |
| mouse IgG1. | |
| Purification Method | |
| Ion exchange column. | |
| Storage Procedures | |
| In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C. | |
| Available Conjugates | |
| This antibody is also available conjugated to Biotin and non conjugate form. | |
| Shipping Conditions | |
| Antibody is shipped lyophilized at ambient temperature. | |
| Titer | |
| For intra-cellular staining, use 5-10 µl/1,000,000 cells. Wash twice with PBS/Azide before adding the appropriate amount of secondary fluorescent reagent. | |
| Cross reactivity | |
| Vimentin antibody will recognize most mammalian Vimentin except mouse and rat. | |
| Precautions | |
| Vimentin Antibody, Biotin is for research use only and not for use in diagnostic or therapeutic procedures. | |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Thank you,
ADMEbio Team
ADMEbio welcomes feedback from our customers.
Thank you,
ADMEbio Team
