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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| ABZ1136-100 | 2 weeks | 100 µL | $499.00 |
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| ABZ1136-20 | 2 weeks | 20 µL | $149.00 | |||
| ABZ1136-50 | 2 weeks | 50 µL | $325.00 |
Product Overview | |
| Name | [KO] HIF1 beta Mouse mAb |
|---|---|
| Accession (Primary) | P27540 |
| Host Species | Mouse |
| Isotype | IgG1 |
| Immunogen | |
| Full length human recombinant protein of human ARNT produced in 293T cell. | |
| Species Reactivity | |
| Reacts With | Rat |
| Calculated MW | |
| Calculated MW: 87 kDa; Observed MW: 110 kDa | |
| Buffer System | |
| Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3. | |
| Storage | |
| Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. | |
| Recommended Dilution | |
| WB: 1/500-1/1000; ICC: 1/100-1/200; FC: 1/50-1/100 | |
| Clonality No. | |
| 2C7 | |
| Purification | |
| Affinity Purified | |
| Conjugation | |
| Unconjugated | |
| Modification | |
| Unmodified | |
| Form | |
| Liquid | |
| Background | |
| HIF-1β is also known as AhR nuclear translocator (ARNT) due to its ability to partner with the aryl hydrocarbon receptor (AhR) to form a heterodimeric transcription factor complex. Together with AhR, HIF-1β plays an important role in xenobiotics metabolism. In addition, a chromosomal translocation leading to a TEL-ARNT fusion protein is associated with acute myeloblastic leukemia. Studies also found that ARNT/HIF-1β expression levels decrease significantly in pancreatic islets from patients with type 2 diabetes, suggesting that HIF-1β plays an important role in pancreatic β-cell function. | |
| Research Field | |
| Cardiovascular | |
Target Information: ( P27540 ) | |
| Name | ARNT |
| Other Names | |
| ARNT; BHLHE2; Aryl hydrocarbon receptor nuclear translocator; ARNT protein; Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor; nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta | |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Thank you,
ADMEbio Team
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Thank you,
ADMEbio Team
