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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| ABZ1152-100 | 2 weeks | 100 µL | $499.00 |
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| ABZ1152-20 | 2 weeks | 20 µL | $149.00 | |||
| ABZ1152-50 | 2 weeks | 50 µL | $325.00 |
Product Overview | |
| Name | [KO] PMS2 Mouse mAb |
|---|---|
| Accession (Primary) | P54278 |
| Host Species | Mouse |
| Isotype | IgG2b |
| Immunogen | |
| Full length human recombinant protein of human PMS2 produced in 293T cell. | |
| Calculated MW | |
| Calculated MW: 96 kDa; Observed MW: 150 kDa | |
| Buffer System | |
| Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3. | |
| Storage | |
| Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. | |
| Recommended Dilution | |
| WB: 1/500-1/1000; IHC: 1/50-1/100; ICC: 1/100-1/200 | |
| Clonality No. | |
| 2G5 | |
| Purification | |
| Affinity Purified | |
| Conjugation | |
| Unconjugated | |
| Modification | |
| Unmodified | |
| Form | |
| Liquid | |
| Background | |
| Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. | |
| Research Field | |
| Epigenetics and Nuclear Signaling | |
Target Information: ( P54278 ) | |
| Name | PMS2 |
| Other Names | |
| DNA mismatch repair gene; DNA mismatch repair protein PMS2; HNPCC4; PMS1 protein homolog 2 | |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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ADMEbio Team
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ADMEbio Team
