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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| ABZ1203-100 | 2 weeks | 100 µL | $499.00 |
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| ABZ1203-20 | 2 weeks | 20 µL | $149.00 | |||
| ABZ1203-50 | 2 weeks | 50 µL | $325.00 |
Product Overview | |
| Name | [KO] PPM1D Mouse mAb |
|---|---|
| Accession (Primary) | O15297 |
| Host Species | Mouse |
| Isotype | IgG1 |
| Immunogen | |
| Purified recombinant human PPM1D protein fragments expressed in E.coli. | |
| Species Reactivity | |
| Reacts With | Rat |
| Calculated MW | |
| Calculated MW: 67 kDa; Observed MW: 80 kDa | |
| Buffer System | |
| Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3. | |
| Storage | |
| Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. | |
| Recommended Dilution | |
| WB: 1/500-1/1000 | |
| Clonality No. | |
| 3E1 | |
| Purification | |
| Affinity Purified | |
| Conjugation | |
| Unconjugated | |
| Modification | |
| Unmodified | |
| Form | |
| Liquid | |
| Background | |
| The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. | |
| Research Field | |
| Signal Transduction | |
Target Information: ( O15297 ) | |
| Name | PPM1D |
| Other Names | |
| protein phosphatase; Mg2+/Mn2+ dependent 1D; WIP1; PP2C-DELTA | |
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Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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ADMEbio Team
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ADMEbio Team
