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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| ABZ2162-100 | 2 weeks | 100 µL | $499.00 |
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| ABZ2162-20 | 2 weeks | 20 µL | $149.00 |
Product Overview | |
| Name | APPBP1 Rabbit mAb |
|---|---|
| Accession (Primary) | Q13564 |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Isotype | IgG |
| Species Reactivity | |
| Reacts With | Human, Rat |
| Calculated MW | |
| Calculated MW: 60 kDa; Observed MW: 60 kDa | |
| Buffer System | |
| Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage | |
| Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. | |
| Recommended Dilution | |
| WB-1:1000-1:5000; FC-1:50-1:100; IP-1:20-1:50 | |
| Purification | |
| Affinity Purified | |
| Conjugation | |
| Unconjugated | |
| Modification | |
| Unmodified | |
| Form | |
| Liquid | |
| Background | |
| Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. | |
Target Information: ( Q13564 ) | |
| Name | NAE1 |
| Gene ID | 8883 |
| Other Names | |
| NEDD8 activating enzyme E1 subunit 1; HPP1; ula-1; APPBP1; A-116A10.1 | |
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ADMEbio Team
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ADMEbio Team
