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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| ABZ2467-100 | 2 weeks | 100 µL | $499.00 |
Select product before adding to cart
|
||
| ABZ2467-20 | 2 weeks | 20 µL | $149.00 |
Product Overview | |
| Name | NEDD4 Rabbit mAb |
|---|---|
| Accession (Primary) | P46934 |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Isotype | IgG |
| Species Reactivity | |
| Reacts With | Human, Mouse, Rat |
| Calculated MW | |
| Calculated MW: 149 kDa; Observed MW: 115 kDa | |
| Buffer System | |
| Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage | |
| Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. | |
| Recommended Dilution | |
| WB-1:1000-1:5000; FC-1:20-1:50; IP-1:20-1:50 | |
| Purification | |
| Affinity Purified | |
| Conjugation | |
| Unconjugated | |
| Modification | |
| Unmodified | |
| Form | |
| Liquid | |
| Background | |
| NEDD4 and similar proteins discovered subsequently became a family of HECT ligases, comprising 9 human proteins including NEDD4, NEDD4-2 (NEDD4L), ITCH, SMURF1, SMURF2, WWP1, WWP2, NEDL1 and NEDL2. NEDD4 is a highly evolutionarily conserved protein from yeast to man, and was initially cloned as a highly expressed gene in the early embryonic brain. NEDD4 is frequently overexpressed in many different types of cancer, and decreased levels of NEDD4 can also be associated with cancer. It can be a potential therapeutic target for the treatment of human cancer. (PMID: 25527121). The human NEDD4 gene is located on chromosome 15q21. 3 and comprises 30 exons (HGNC:7727) shown to encode a ~120 KDa protein. Otherwise there is a 75 kDa isoform in addition to full length NEDD4 (PMID: 24907641). | |
Target Information: ( P46934 ) | |
| Name | NEDD4 |
| Gene ID | 4734 |
| Other Names | |
| KIAA0093; HECT-type E3 ubiquitin transferase NEDD4; EC:2.3.2.26; E3 ubiquitin-protein ligase NEDD4; Cell proliferation-inducing gene 53 protein | |
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ADMEbio Team
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ADMEbio Team
