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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| ABZ2540-100 | 2 weeks | 100 µL | $499.00 |
Select product before adding to cart
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| ABZ2540-20 | 2 weeks | 20 µL | $149.00 |
Product Overview | |
| Name | IRS1 Rabbit mAb |
|---|---|
| Accession (Primary) | P35568 |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Isotype | IgG |
| Species Reactivity | |
| Reacts With | Human |
| Calculated MW | |
| Calculated MW: 132 kDa; Observed MW: 170 kDa | |
| Buffer System | |
| Liquid in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. | |
| Storage | |
| Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. | |
| Recommended Dilution | |
| WB-1:1000-1:5000; IHC:1:20-1:50; ICC/IF-1:50-1:200; FC-1:20 | |
| Purification | |
| Affinity Chromatography | |
| Conjugation | |
| Unconjugated | |
| Modification | |
| Unmodified | |
| Form | |
| Liquid | |
| Background | |
| Ins receptor substrate 1 (IRS1) was the first cloned and characterized member of the IRS family which are involved in ins receptor (IR) and ins-like growth factor I receptor (IGF-IR) signaling. IRS1 is phosphorylated by ins receptor tyrosine kinase and is involved in various cellular processes including DNA repair fidelity, transcriptional activity, and cell growth can support tumor development and progression. Mutations in this gene are associated with type II diabetes and susceptibility to ins resistance. IRS1 has a predicted molecular weight of 132 kDa, however, as a result of its extensive serine phosphorylation it separates on a SDS gel as a band of approximately 160-185 kDa. | |
Target Information: ( P35568 ) | |
| Name | IRS1 |
| Gene ID | 3667 |
| Other Names | |
| IRS1; Insulin receptor substrate 1; IRS-1 | |
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ADMEbio Team
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ADMEbio Team
