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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| ABZ2745-100 | 2 weeks | 100 µL | $499.00 |
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| ABZ2745-20 | 2 weeks | 20 µL | $149.00 |
Product Overview | |
| Name | KIAA0652/ATG13 Rabbit mAb |
|---|---|
| Accession (Primary) | O75143 |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Isotype | IgG |
| Species Reactivity | |
| Reacts With | Human, Mouse, Rat |
| Calculated MW | |
| Calculated MW: 57 kDa; Observed MW: 72 kDa | |
| Buffer System | |
| Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage | |
| Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. | |
| Recommended Dilution | |
| WB-1:500-1:1000; FC-1:50-1:100; IP-1:20-1:50 | |
| Purification | |
| Affinity Purified | |
| Conjugation | |
| Unconjugated | |
| Modification | |
| Unmodified | |
| Form | |
| Liquid | |
| Background | |
| ATG13 is a protein kinase required for autophagy. Overexpression of Atg1 suppresses the defects in autophagy observed in Atg13 mutants. Autophagy requires a direct association between Atg1 and Atg13, and is inhibited by TOR-dependent phosphorylation of Atg13 under high-nutrient conditions. Similarly, mammalian Atg13 forms a complex with the Atg1 homologues ULK1/2, along with FIP200, which localizes to autophagic isolation membranes and regulates autophagosome biogenesis. mTOR phosphorylates both Atg13 and ULK1, suppressing ULK1 kinase activity and autophagy. ULK1 can directly phosphorylate Atg13 at a yet unidentified site, presumably to promote autophagy. Additional studies suggest that Atg13 and FIP200 can function independently of ULK1 and ULK2 to induce autophagy through an unknown mechanism. | |
Target Information: ( O75143 ) | |
| Name | ATG13 |
| Gene ID | 9776 |
| Other Names | |
| Autophagy-related protein 13; KIAA0652; PARATARG8; ATG13 | |
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ADMEbio Team
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ADMEbio Team
