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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| ABZ3210-100 | 2 weeks | 100 µL | $499.00 |
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| ABZ3210-20 | 2 weeks | 20 µL | $149.00 |
Product Overview | |
| Name | TRIM23/ARD1 Rabbit mAb |
|---|---|
| Accession (Primary) | P36406 |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Isotype | IgG |
| Species Reactivity | |
| Reacts With | Human, Mouse, Rat |
| Calculated MW | |
| Calculated MW: 64 kDa; Observed MW: 64 kDa | |
| Buffer System | |
| Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage | |
| Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. | |
| Recommended Dilution | |
| WB-1:2000-1:5000 | |
| Purification | |
| Affinity Purified | |
| Conjugation | |
| Unconjugated | |
| Modification | |
| Unmodified | |
| Form | |
| Liquid | |
| Background | |
| Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes (PubMed:28871090). | |
Target Information: ( P36406 ) | |
| Name | TRIM23 |
| Gene ID | 373 |
| Other Names | |
| ARD1; ARFD1; RNF46; ADP ribosylation factor domain protein 1; ADP-ribosylation factor domain-containing protein 1; ARF domain protein 1; | |
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ADMEbio Team
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ADMEbio Team
