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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| ABZ3705-100 | 2 weeks | 100 µL | $499.00 |
Select product before adding to cart
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| ABZ3705-20 | 2 weeks | 20 µL | $149.00 |
Product Overview | |
| Name | RIP Rabbit mAb |
|---|---|
| Accession (Primary) | Q60855 |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Isotype | IgG |
| Species Reactivity | |
| Reacts With | Mouse |
| Calculated MW | |
| Calculated MW:75 kDa;Observed MW: 75 kDa | |
| Buffer System | |
| Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage | |
| Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. | |
| Recommended Dilution | |
| WB-1:500-1:1000; IF-1:100-1:200; FC-1:200-1:500; IP-1:20-1:50 | |
| Purification | |
| Affinity Purified | |
| Conjugation | |
| Unconjugated | |
| Modification | |
| Unmodified | |
| Form | |
| Liquid | |
| Background | |
| Receptor-interacting serine/threonine-protein kinase 1 is a serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. RIPK1 is phosphorylated at several sites within the kinase domain that are sensitive to Nec-1, including Ser14, Ser15, Ser161, and Ser166. | |
Target Information: ( Q60855 ) | |
| Name | Ripk1 |
| Gene ID | 19766 |
| Other Names | |
| Cell death protein RIP,Receptor-interacting protein 1 | |
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ADMEbio Team
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ADMEbio Team
