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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| ABZ4312-100 | 2 weeks | 100 µL | $499.00 |
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| ABZ4312-20 | 2 weeks | 20 µL | $149.00 |
Product Overview | |
| Name | Acetyl-NF-KB p65 (Lys314/Lys315) (6D6) Mouse mAb |
|---|---|
| Accession (Primary) | Q04206 |
| Host Species | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Species Reactivity | |
| Reacts With | Human, Mouse, Rat |
| Buffer System | |
| Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. | |
| Storage | |
| Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. | |
| Recommended Dilution | |
| IHC-1:50-1:100 | |
| Purification | |
| Affinity Purified | |
| Conjugation | |
| Unconjugated | |
| Modification | |
| Acetylated | |
| Form | |
| Liquid | |
| Background | |
| Nuclear factor kB (NF-kB) is a sequence-specific DNA-binding protein complex which regulates the expression of viral genomes, including the human immunodeficiency virus, and a variety of cellular genes, particularly those involved in immune and inflammatory responses. The members of the NF-kB family in mammalian cells include the proto-oncogene c-Rel, p50/p105 (NFkB1), p65 (RelA), p52/p100 (NFkB2), and RelB. All of these proteins share a conserved 300-amino acid region known as the Rel homology domain which is responsible for DNA binding, dimerization, and nuclear translocation of NF-kB. The p65 subunit is a major component of NF-kB complexes and is responsible for trans-activation. NF-kB heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kB p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of IkB upon NF-kB the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kB complex. It associates with chromatin at the NF-kB promoter region via association with DDX1. This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human RELA. | |
Target Information: ( Q04206 ) | |
| Name | RELA |
| Gene ID | 5970 |
| Other Names | |
| NFKB3; RELA; TF65; Transcription factor p65; p65; NFkB | |
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Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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ADMEbio Team
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ADMEbio Team
