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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| ABZ4366-100 | 2 weeks | 100 µL | $499.00 |
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| ABZ4366-20 | 2 weeks | 20 µL | $149.00 |
Product Overview | |
| Name | Phospho-4E BP1 (Thr70) Rabbit pAb |
|---|---|
| Accession (Primary) | Q13541 |
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Species Reactivity | |
| Reacts With | Human, Mouse, Rat |
| Buffer System | |
| Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. | |
| Storage | |
| Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. | |
| Recommended Dilution | |
| IHC-1:100-1:300; IF-1:50-1:200; ELISA-1:5000 | |
| Purification | |
| Affinity Purified | |
| Conjugation | |
| Unconjugated | |
| Modification | |
| Phosphorylated | |
| Form | |
| Liquid | |
| Background | |
| Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity. | |
Target Information: ( Q13541 ) | |
| Name | EIF4EBP1 |
| Gene ID | 1978 |
| Other Names | |
| EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I | |
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ADMEbio Team
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ADMEbio Team
