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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| ABZ4471-100 | 2 weeks | 100 µL | $499.00 |
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| ABZ4471-20 | 2 weeks | 20 µL | $149.00 |
Product Overview | |
| Name | Phospho-JAK2/3 (Tyr966/939) Rabbit pAb |
|---|---|
| Accession (Primary) | O60674 |
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Species Reactivity | |
| Reacts With | Human, Mouse, Rat |
| Calculated MW | |
| Calculated MW: 131 kDa; Observed MW: 120-130 kDa | |
| Buffer System | |
| Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. | |
| Storage | |
| Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. | |
| Recommended Dilution | |
| WB-1:500-1:2000; IHC-1:50-1:300 | |
| Purification | |
| Affinity Purified | |
| Conjugation | |
| Unconjugated | |
| Modification | |
| Phosphorylated | |
| Form | |
| Liquid | |
| Background | |
| Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. | |
Target Information: ( O60674 ) | |
| Name | JAK2/JAK3 |
| Gene ID | 3717/3718 |
| Other Names | |
| Tyrosine-protein kinase JAK2/JAK3 (EC 2.7.10.2; Janus kinase 2/Janus kinase 3; JAK-2/JAK-3) | |
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Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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ADMEbio Team
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ADMEbio Team
