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[KO]LRP1 Rabbit mAb

Catalog #: ABZ4658
Application: WB, IF, FC, IP, ICC, IHC-F, IHC-P
Uniprot Id: Q07954
Reactivity: Human, Mouse, Rat
Isotype: IgG

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Western blot analysis of LRP1 in HeLa(WT) and LRP1-Knockout HeLa(KO) using LRP1 antibody.
Immunocytochemistry analysis of LRP1 (green) in U87-MG using LRP1 antibody,and DAPI(blue).
Western blot analysis of LRP1 in mouse brain lysates using LRP1 antibody.
Western blot analysis of LRP1 in rat Brain, C6 lysates using LRP1 antibody
Immunohistochemistry analysis of paraffin-embedded Human Cholangiocarcinoma using LRP1 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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	ABZ4658-20	2 weeks	20 µL	reduce add	$149.00	Add to Cart INQUIRE Select product before adding to cart

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Datasheet
Citations
Reviews

Species Reactivity
Product Overview
Name	[KO]LRP1 Rabbit mAb
Accession (Primary)	Q07954
Host Species	Rabbit
Clonality	Monoclonal
Isotype	IgG
Reacts With	Human, Mouse, Rat
Calculated MW
Calculated MW: 505 kDa; Observed MW: 85 kDa
Buffer System
1xPBS(pH 7.4), 150mM NaCl, 50% Glycerol, 0.02% Sodium azide and 0.05% BSA
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Recommended Dilution
WB-1:2000-1:10000; IHC-1:100-1:1000; ICC/IF-1:50-1:100; FC-1:50-1:100; IP-1:20-1:50
Purification
Affinity Purified
Conjugation
Unconjugated
Modification
Unmodified
Form
Liquid
Background
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients.
Target Information: ( Q07954 )
Name	LRP1
Gene ID	4035
Other Names
APR; KPA; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R; IGFBP-3R; IGFBP3R1

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