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>   Home   >   Products   >   Primary Antibodies   >   [KO]DAB2 Rabbit mAb   

[KO]DAB2 Rabbit mAb

 
Catalog #
ABZ4766
Application
WB, IP, IHC-P
Uniprot Id
P98082
Reactivity
Human, Mouse, Rat
Isotype
IgG
 
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  • Western blot analysis of DAB2 in HepG2, U2OS, U251 lysates using DAB2 antibody.
  • Immunohistochemistry analysis of paraffin-embedded Human lung cancer using DAB2 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
 Catalog #AvailabilitySizeQuantityUnit Price Save For Later Wish List
ABZ4766-100 2 weeks 100 µL $499.00
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ABZ4766-20 2 weeks 20 µL $149.00
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Product Overview

Name[KO]DAB2 Rabbit mAb
Accession (Primary)P98082
Host SpeciesRabbit
ClonalityMonoclonal
IsotypeIgG
Species Reactivity
Reacts WithHuman, Mouse, Rat
Calculated MW
Calculated MW: 82 kDa; Observed MW: 96 kDa
Buffer System
Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Recommended Dilution
WB-1:500-1:1000; IHC-1:200-1:500; IP-1:20-1:50
Purification
Affinity Purified
Conjugation
Unconjugated
Modification
Unmodified
Form
Liquid
Background
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Target Information: ( P98082 )

NameDAB2
Gene ID1601
Other Names
DOC2; DOC-2; DAB2; Adaptor molecule disabled-2; DAB 2; Dab; mitogen-responsive phosphoprotein; homolog 2 (Drosophila);
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