| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| ABZ4766-100 | 2 weeks | 100 µL | $499.00 |
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| ABZ4766-20 | 2 weeks | 20 µL | $149.00 |
Product Overview | |
| Name | [KO]DAB2 Rabbit mAb |
|---|---|
| Accession (Primary) | P98082 |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Isotype | IgG |
| Species Reactivity | |
| Reacts With | Human, Mouse, Rat |
| Calculated MW | |
| Calculated MW: 82 kDa; Observed MW: 96 kDa | |
| Buffer System | |
| Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage | |
| Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. | |
| Recommended Dilution | |
| WB-1:500-1:1000; IHC-1:200-1:500; IP-1:20-1:50 | |
| Purification | |
| Affinity Purified | |
| Conjugation | |
| Unconjugated | |
| Modification | |
| Unmodified | |
| Form | |
| Liquid | |
| Background | |
| This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. | |
Target Information: ( P98082 ) | |
| Name | DAB2 |
| Gene ID | 1601 |
| Other Names | |
| DOC2; DOC-2; DAB2; Adaptor molecule disabled-2; DAB 2; Dab; mitogen-responsive phosphoprotein; homolog 2 (Drosophila); | |
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