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![[KO]Annexin A1 (5E4D8) Mouse mAb ABZ4809](http://img.admebio.com/products/SEAC100001/20260405/ABZ4809-WB-1.jpg)
![[KO]Annexin A1 (5E4D8) Mouse mAb ABZ4809](http://img.admebio.com/products_thumb/SEAC100001/20260405/ABZ4809-WB-1.jpg)
| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| ABZ4809-100 | 2 weeks | 100 µL | $499.00 |
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| ABZ4809-20 | 2 weeks | 20 µL | $149.00 |
Product Overview | |
| Name | [KO]Annexin A1 (5E4D8) Mouse mAb |
|---|---|
| Accession (Primary) | P04083 |
| Host Species | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Species Reactivity | |
| Reacts With | Human, Mouse, Rat, Cat |
| Calculated MW | |
| Calculated MW: 39 kDa; Observed MW: 39 kDa | |
| Buffer System | |
| Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. | |
| Storage | |
| Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. | |
| Recommended Dilution | |
| WB-1:500-1:1000 | |
| Purification | |
| Affinity Purified | |
| Conjugation | |
| Unconjugated | |
| Modification | |
| Unmodified | |
| Form | |
| Liquid | |
| Background | |
| Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response . Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca2+ and can bind up to eight Ca2+ ions . Displays Ca2+-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca2+-dependent interaction between phagosomes and the actin cytoskeleton . | |
Target Information: ( P04083 ) | |
| Name | ANXA1 |
| Gene ID | 301 |
| Other Names | |
| ANXA1; ANX1; LPC1; Annexin A1; Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35 | |
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