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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| GRF0006-1 | 1 µg | $120.00 |
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| GRF0006-5 | 5 µg | $290.00 | ||||
| GRF0006-100 | 100 µg | $2,400.00 |
Product Overview | |
| Name | Activin-A Human Plant-Active |
|---|---|
| Description | |
| Activin-A Human Recombinant, Plant-Active | |
| Accession (Primary) | P08476 |
| Synonyms | |
| Inhba, Inhibin beta A, FSH releasing protein. | |
| Introduction | |
| Activins are homodimers or heterodimers of the different β subunit isoforms, part of the TGFβ family. Mature Activin A has two 116 amino acids residues βA subunits (βA-βA). Activin displays an extensive variety of biological activities, including mesoderm induction, neural cell differentiation, bone remodelling, haematopoiesis, and reproductive physiology. Activins takes part in the production and regulation of hormones such as FSH, LH, GnRH and ACTH. Cells that are identified to express Activin A include fibroblasts, endothelial cells, hepatocytes, vascular smooth muscle cells, macrophages, keratinocytes, osteoclasts, bone marrow monocytes, prostatic epithelium, neurons, chondrocytes, osteoblasts, Leydig cells, Sertoli cells, and ovarian granulosa cells. | |
| Source | |
| E.Coli. | |
| Physical Appearance | |
| Lyophilized freeze dried powder. | |
| Formulation | |
| Mouse Activin-A lyophilized from a concentrated 1mg/ml protein solution containing 0.1% TFA. | |
| Stability | |
| Lyophilized Activin-A although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Activin-A should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95% as obsereved by SDS-PAGE. | |
| Amino acid sequence | |
| MGLECDGKVN ICCKKQFFVS FKDIGWNDWI IAPSGYHANY CEGECPSHIA GTSGSSLSFH STVINHYRMR GHSPFANLKS CCVPTKLRPM SMLYYDDGQN IIKKDIQNMI VEECGCS. | |
| Biological Activity | |
| Biological activity is assessed by the ability to induce cytoxicity of MPC-11 cells and was found to be 8.8ng/ml corresponding to a specific activity of 1.1 x 10 5 units/mg. | |
| Solubility | |
| Murine INHBA protein should be reconstituted in distilled pyrogen free water to a concentration of 100ug /ml which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| Activin-A Human Plant-Active is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P08476 ) | |
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ADMEbio Team
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