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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| NTP0005-2 | 2 µg | $120.00 |
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| NTP0005-10 | 10 µg | $290.00 | ||||
| NTP0005-1 | 1 mg | $7,680.00 |
Product Overview | |
| Name | Angiostatin K1-4 |
|---|---|
| Description | |
| Angiostatin Kringles 1-4 Human | |
| Synonyms | |
| Angiotensinogen, Serpin A8, ANHU, SERPINA8. | |
| Introduction | |
| Angiotensin is an oligopeptide in the blood that causes vasoconstriction, increased blood pressure, and release of aldosterone from the adrenal cortex. It is a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays an important role in the renin-angiotensin system. The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. | |
| Source | |
| Synthetic. | |
| Physical Appearance | |
| Sterile Filtered white lyophilized powder. | |
| Stability | |
| Lyophilized Angiotensin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Serpin A8 should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 98.0% as determined by RP-HPLC. | |
| Amino acid sequence | |
| Asn-Arg-Val-Tyr-Val-His-Pro-Phe-OH. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Angiotensin in sterile 18MΩ-cm H2O not less than 100 µg/ml or more than 10 mg/ml solutions. | |
| Precautions | |
| Angiostatin K1-4 is for research use only and not for use in diagnostic or therapeutic procedures. | |
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