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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CHK0003-50 | 50 µg | $800.00 |
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| CHK0003-100 | 100 µg | $1,200.00 | ||||
| CHK0003-1 | 1 mg | $4,320.00 |
Product Overview | |
| Name | BCA1 Macaque |
|---|---|
| Description | |
| BCA-1/ BLC (CXCL13) Rhesus Macaque Recombinant | |
| Accession (Primary) | Q8HYN9 |
| Synonyms | |
| C-X-C motif chemokine 13, B lymphocyte chemoattractant, CXC chemokine BLC, Small-inducible cytokine B13, Cxcl13, Blc, Scyb13. | |
| Introduction | |
| BCA-1 is a CXC chemokine that is highly expressed in thesecondary lymphoid organs, such as follicles of the spleen, lymph nodes, and Peyer's patches. CXCL13 promotes the migration of B lymphocytes (compared to T cells and macrophages), by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR1). BCA1 therefore function in the homing of B lymphocytes to follicles. Human BCA-1 shares a 64% amino acid sequence similarity with the mouse protein and 23 - 34% amino acid sequence identity with other known CXC chemokines. Recombinant or chemically synthesized BCA1 is a potent chemoattractant for B lymphocytes but not T lymphocytes, monocytes or neutrophils. BLR1, a G protein-coupled receptor originally isolated from Burkitt’s lymphoma cells, has now been shown to be the specific receptor for BCA1. Among cells of the hematopoietic lineages, the expression of BLR-1, now designated CXCR-5, is restricted to B lymphocytes and a subpopulation of T helper memory cells. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The BCA1 protein was lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA. | |
| Stability | |
| Lyophilized BCA1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BCA1 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 97.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| ILEAHYTNLK CRCSGVISTV VGLNIIDRIQ VTPPGNGCPK TEVVIWTKMK KVICVNPRAK WLQRLLRHVQ SKSLSSTPQA PVSKRRAA. | |
| Biological Activity | |
| The ED 50 , as measured by its ability to chemoattract human CXCR5-transfected mouse BaF3 cells, is less than 2 µg/ml. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized CXCL13 in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| BCA1 Macaque is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q8HYN9 ) | |
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ADMEbio Team
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