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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CDA0131-2 | 7 days | 2 µg | $120.00 |
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| CDA0131-10 | 7 days | 10 µg | $290.00 | |||
| CDA0131-100 | 7 days | 100 µg | $1,920.00 |
Product Overview | |
| Name | CD99L2 Mouse |
|---|---|
| Description | |
| CD99 Molecule Like 2 Mouse Recombinant | |
| Accession (Primary) | Q8BIF0 |
| Synonyms | |
| Cytidine deaminase, Cytidine aminohydrolase, CDA, CDD. | |
| Introduction | |
| Cytidine deaminase (CDA) is an enzyme that scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. CDA is one of several deaminases responsible for maintaining the cellular pyrimidine pool. CDA also catalyzes the deamination of chemotherapeutic cytosine nucleoside analogs such as Ara-C and 5-azacytidine, which results in the loss of their cytotoxic and antitumor function. CDA can form homotetramers and is generally expressed in granulocytes. Mutations in the CDA gene are linked to decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered colorless solution. | |
| Formulation | |
| The CDA solution (0.5mg/ml) contains 20mM Tris-HCl Buffer (pH 8.0), 1mM DTT, 2mM EDTA, 100mM NaCl and 40% Glycerol. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 90.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| MGSSHHHHHH SSGLVPRGSH MAQKRPACTL KPECVQQLLV CSQEAKQSAY CPYSHFPVGA ALLTQEGRIF KGCNIENACY PLGICAERTA IQKAVSEGYK DFRAIAIASD MQDDFISPCG ACRQVMREFG TNWPVYMTKP DGTYIVMTVQ ELLPSSFGPE DLQKTQ. | |
| Biological Activity | |
| Specific activity is > 10,000pmol/min/ug, and is defined as the amount of required to deaminate 1.0pmole of cytidine per min at pH 7.5 at 25C. | |
| Precautions | |
| CD99L2 Mouse is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q8BIF0 ) | |
Background |
The CD99L2 human recombinant, a variant of the CD99L2 protein, has gained substantial attention in biomedical research due to its intriguing molecular characteristics and potential implications in various biological processes. CD99L2, a member of the CD99 family of proteins, plays diverse roles in cellular adhesion, migration, and signal transduction. The CD99L2 human recombinant, generated through recombinant DNA technology, offers a valuable tool for investigating the intricate functions and therapeutic potential of this protein. Understanding the molecular characteristics of CD99L2 is pivotal in unraveling its functional significance. CD99L2 belongs to the immunoglobulin superfamily and is primarily expressed on the cell surface. It exhibits unique structural features, including extracellular immunoglobulin-like domains and intracellular signaling motifs. These characteristics contribute to the complexity of CD99L2 and its ability to interact with various cellular components and modulate signaling pathways. CD99L2 plays diverse roles in different physiological contexts. It is involved in cellular adhesion processes, regulating cell-cell interactions and migration in various tissues. Additionally, CD99L2 has been implicated in immune responses, particularly in the modulation of T-cell activation and leukocyte migration. The precise mechanisms underlying these functions are still being elucidated, highlighting the need for further investigation. The CD99L2 human recombinant offers exciting prospects for research and therapeutic applications. By utilizing this recombinant protein, scientists can investigate the role of CD99L2 in disease pathogenesis, explore its interactions with other molecules, and potentially develop targeted therapies. CD99L2 has been implicated in cancer progression, immune disorders, and neurodevelopmental conditions, making it a promising candidate for novel therapeutic interventions. This research aims to provide a comprehensive analysis of the CD99L2 human recombinant, focusing on its molecular characteristics, biological roles, and potential therapeutic implications. By shedding light on the intricate nature of CD99L2, we aim to contribute to a deeper understanding of its functional significance and pave the way for future research and therapeutic advancements. |
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ADMEbio Team
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