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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CDA0142-1 | 7 days | 1 µg | $120.00 |
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| CDA0142-5 | 7 days | 5 µg | $290.00 | |||
| CDA0142-50 | 7 days | 50 µg | $1,920.00 |
Product Overview | |
| Name | MS4A1 Human |
|---|---|
| Description | |
| Membrane Spanning 4-Domains A1 Human Recombinant | |
| Synonyms | |
| MSH6, GTBP, HNPCC5, HSAP, DNA mismatch repair protein Msh6, MutS-alpha 160 kDa subunit, G/T mismatch-binding protein, hMSH6, p160, GTMBP. | |
| Introduction | |
| MSH6 deficiency result in hereditary non-polyposis colorectal cancer (Lynch syndrome). HNPCC is an autosomal, dominantly inherited disease linked with rise in cancer susceptibility. MSH6 is is known by its familial predisposition to premature onset colorectal carcinoma (crc). MSH6 is involved in repairing DNA. MSH6 protein repairs mistakes that occure during DNA replication in preparation for cell division. The MSH6 protein bonds with MSH2 protein and form an active protein complex which recognizes specific parts on the DNA where mistakes have been made during DNA replication. MLH1-PMS2 protein complex, afterwards takes over with the repair. MSH6 gene is part of the set of the mismatch repair (MMR) genes. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered clear solution. | |
| Formulation | |
| MSH6 is supplied in 50mM Tris-HCl, pH-7.5, 10mM L-glutathione (reduced). | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles. | |
| Precautions | |
| MS4A1 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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ADMEbio Team
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ADMEbio Team
