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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CHK0050-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
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| CHK0050-25 | 7 days | 25 µg | $290.00 | |||
| CHK0050-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | GRO a Human |
|---|---|
| Description | |
| GRO-Alpha Human Recombinant (CXCL1) | |
| Accession (Primary) | P09341 |
| Synonyms | |
| Growth-regulated protein alpha, CXCL1, Melanoma growth stimulatory activity, MGSA, Neutrophil-activating protein 3, NAP-3, GRO-alpha(1-73), chemokine (C-X-C motif) ligand 1, GRO1, GROa, SCYB1, MGSA-a, MGSA alpha. | |
| Introduction | |
| Chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-?). It is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis. This chemokine elicits its effects by signaling through the chemokine receptor CXCR2. The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered colorless solution. | |
| Formulation | |
| CXCL1 in 20mM Tris-HCL pH-8 and 10% glycerol. | |
| Stability | |
| Liquid CXCL1 although stable at 10°C for 1 week, should be stored below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 90.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| MGSSHHHHHH SSGLVPRGSH MASVATELRC QCLQTLQGIH PKNIQSVNVK SPGPHCAQTE VIATLKNGRK ACLNPASPIV KKIIEKMLNS DKSN. | |
| Precautions | |
| GRO a Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P09341 ) | |
References |
Title :Deficient inflammatory response to UV radiation in neonatal mice. Publication :Published online before print March 16, 2007, doi: 10.1189/jlb.1206729 June 2007 Journal of Leukocyte Biology vol. 81 no. 6 1352-1361 Link : GRO a prospec publication |
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ADMEbio Team
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