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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CHK0128-5 | 7 days | 5 µg | $120.00 |
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| CHK0128-20 | 7 days | 20 µg | $290.00 | |||
| CHK0128-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | MIP 1b Rat |
|---|---|
| Description | |
| Macrophage Inflammatory Protein-1 beta Rat Recombinant (CCL4) | |
| Accession (Primary) | P50230 |
| Immunogen | |
| r.Human MIP-3. | |
| Synonyms | |
| C-C motif chemokine 23, Small-inducible cytokine A23, Macrophage inflammatory protein 3, Myeloid progenitor inhibitory factor 1, CK-beta-8, MIP-3, MPIF-1, CKB-8, CCL23, MIP3, MPIF1, SCYA23, CKb8, Ckb-8-1. | |
| Introduction | |
| CCL23 (MIP-3) is a ligand for the CCR1chemokine receptor. CCL23 is one of several cytokine genes clustered on the q-arm of chromosome 17, in a locus containing several other CC chemokines. MIP-3 chemoattracts monocytes, resting T-lymphocytes and neutrophils, but not activated lymphocytes. Furthermore, it was shown that MIP-3 inhibits colony formation of bone marrow myeloid immature progenitors. MIP-3 is mainly expressed in lung and liver tissue, but can be also found in bone marrow and placenta, as well as in some cell lines of myeloid origin. Alternative splicing of the CCL23 gene produces 2 mRNAs which encode a short (CK?8) and a long (CK?81) isoform of the MIP-3. CK?8 cDNA encodes a 120 amino acid residue precursor protein with a putative 21 a.a. residue signal peptide which is cleaved to generate a 99 a.a. residue mature CK?8 (a.a. 22-120). Further N-terminal processing of the 99 a.a. residue variant can produce a 75 a.a. residue CK?8 (a.a. 46-120) which is considerably more active than the 99 a.a. residue variant. MIP-3 may be involved in the malignant progression of certain human cancer cells which overexpress ErbB2 through the transactivation of ErbB2 tyrosine kinase. MIP-3 may also be involved in angiogenesis via upregulation of matrix metalloproteinase MMP-2 expression. | |
| Formulation | |
| 1mg/ml in PBS (after reconstitution). | |
| Solubility | |
| Reconstitute with sterile H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. | |
| Type | |
| Mouse Anti Human Monoclonal. | |
| Clone | |
| YNR-HMIP3. | |
| Ig Subclass | |
| Mouse IgG1. | |
| Purification Method | |
| Ion exchange. | |
| Storage Procedures | |
| In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C. | |
| Shipping Conditions | |
| Antibody is shipped lyophilized at ambient temperature. | |
| Titer | |
| By direct ELISA, 1:10,000 dilution will yield 0.5 O.D using alkaline phosphatase conjugated rabbit anti-mouse Ig (Jackson Laboratories). | |
| Precautions | |
| MIP 1b Rat is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P50230 ) | |
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ADMEbio Team
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ADMEbio Team
