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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CHK0137-1 | 7 days | 1 µg | $120.00 |
Select product before adding to cart
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| CHK0137-5 | 7 days | 5 µg | $290.00 | |||
| CHK0137-50 | 7 days | 50 µg | $1,760.00 |
Product Overview | |
| Name | MIP 4 Human, His |
|---|---|
| Description | |
| Macrophage Inflammatory protein-4 (CCL18) Human Recombinant, His-Tag | |
| Accession (Primary) | P55774 |
| Synonyms | |
| Small inducible cytokine A15 precursor, CCL15, Macrophage inflammatory protein 5, MIP-5, MIP5, Chemokine CC-2, HCC-2, NCC-3, MIP- 1 delta, Leukotactin-1, LKN-1, Mrp-2b, C-C motif chemokine 15. | |
| Introduction | |
| CCL15, a new human CC chemokine, was isolated from a human fetal spleen cDNA library. CCL15 cDNA encodes a predicted 113 amino acid (aa) protein containing a putative signal peptide of 21 amino acids that is cleaved to generate a 92 aa residue mature protein. Within the CC family members, human CCL15 shares 45%, 44%, 35%, and 30% aa homology with mouse C10, human MPIF-1, human HCC-1, and mouse MIP-1?, respectively. The gene for MIP-5 is found on chromosome 17 where the genes for most of the human CC chemokines are located. Human CCL15 is expressed in T and B lymphocytes, NK cells, monocytes and monocyte-derived dendritic cells. Human MIP-5 is chemotactic for T cells and monocytes and has been shown to induce calcium flux in human CCR-1-transfected cells. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| MIP5 was lyophilized from a 0.2 µm filtered concentrated solution containing PBS, pH-7.4. | |
| Stability | |
| Lyophilized MIP-5 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL15 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| SFHFAADCCT SYISQSIPCS LMKSYFETSS ECSKPGVIFL TKKGRQVCAK PSGPGVQDCM KKLKPYSI. | |
| Biological Activity | |
| Measured by its ability to chemoattract THP-1 human acute monocytic leukemia cells. The ED 50 for this effect is typically 2-4ng/ml. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized MIP5 in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| MIP 4 Human, His is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P55774 ) | |
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ADMEbio Team
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