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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CHK0146-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
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| CHK0146-20 | 7 days | 20 µg | $290.00 | |||
| CHK0146-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | PF 4 Mouse |
|---|---|
| Description | |
| Platelet Factor-4 Mouse Recombinant (CXCL4) | |
| Accession (Primary) | Q9Z126 |
| Synonyms | |
| CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298. | |
| Introduction | |
| Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy. | |
| Source | |
| Human Platelets. | |
| Physical Appearance | |
| Sterile Filtered white lyophilized powder. | |
| Formulation | |
| The CXCL4 protein was lyophilized in PBS buffer pH-7.4. | |
| Stability | |
| Human CXCL4 although stable at 25°C 1 week, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| The sequence of the first four N-terminal amino acids was determined and was found to be Glu-Ala-Glu-Glu. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized CXCL4 in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Activity Control | |
| Binding of HIT-antibodies. | |
| Precautions | |
| PF 4 Mouse is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q9Z126 ) | |
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ADMEbio Team
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ADMEbio Team
