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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CHK0147-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
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| CHK0147-20 | 7 days | 20 µg | $290.00 | |||
| CHK0147-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | PF 4 Protein |
|---|---|
| Description | |
| Platelet Factor-4 Human (CXCL4) | |
| Accession (Primary) | P02776 |
| Synonyms | |
| CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298. | |
| Introduction | |
| Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets.PF4’s major physiologic role appears to be neutralization of molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Furthermore, it is used as an inhibitor in the angiogenesis during tumor therapy. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Lyophilized from a 0.2 µm filtered concentrated solution in 20 mM PB and 500mM NaCl, pH 7.0. | |
| Stability | |
| Lyophilized CXCL4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Platelet Factor-4 should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles . | |
| Purity | |
| Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| ESSFPATFVP LPADSEGGED EDLQCVCLKT TSGINPRHIS SLEVIGAGTH CPSPQLLATK KTGRKICLDQ QRPLYKKILK KLLDGDES. | |
| Biological Activity | |
| The biological activity determined by a chemotaxis bioassay using human neutrophils is 10-100ng/ml. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Platelet Factor-4 in sterile 18MΩ-cm H 2 O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| PF 4 Protein is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P02776 ) | |
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ADMEbio Team
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