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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CHK0154-5 | 7 days | 5 µg | $120.00 |
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| CHK0154-20 | 7 days | 20 µg | $290.00 | |||
| CHK0154-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | Rantes Rat |
|---|---|
| Description | |
| Rantes Rat Recombinant (CCL5) | |
| Accession (Primary) | P50231 |
| Synonyms | |
| C-C motif chemokine 5, Small-inducible cytokine A5, T-cell-specific protein RANTES, CCL5. | |
| Introduction | |
| Regulated upon Activation, Normal T-cell Expressed, and Secreted or RANTES is an 8 kDa protein classified as a chemotactic cytokine or chemokine. It has recently been renamed CCL5. RANTES is chemotactic for T cells, eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines (i.e. IL-2 and IFN-?) that are released by T cells, RANTES also induces the proliferation and activation of certain natural killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells. It is also a HIV-suppressive factor released from CD8+ T cells. This chemokine has been localized to chromosome 17 in humans. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Rantes protein was lyophilized from a 0.2 µm filtered concentrated solution in 20mM PB pH 6.0 and 500mM NaCl. | |
| Stability | |
| Lyophilized Rantes although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL5 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| SPHASDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS. | |
| Biological Activity | |
| The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 1.0-10 ng/ml. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Rantes in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| Rantes Rat is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P50231 ) | |
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ADMEbio Team
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ADMEbio Team
