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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0033-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
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| CYK0033-20 | 7 days | 20 µg | $290.00 | |||
| CYK0033-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | ANGPTL3 (243-460) Human |
|---|---|
| Description | |
| Angiopoietin-like Protein 3 (243-460 a.a.) Human Recombinant | |
| Accession (Primary) | Q9Y5C1 |
| Immunogen | |
| Anti-human ANGPTL3 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human ANGPTL3 protein 243-460 amino acids purified from E. coli. | |
| Synonyms | |
| Angiopoietin Like 3, Angiopoietin 5, ANGPT5, ANG-5, Angiopoietin-Related Protein 3 , Angiopoietin-Like Protein 3, Angiopoietin-Like 3, Angiopoietin-5, FHBL2, ANL3. | |
| Introduction | |
| ANGPTL3 and ANGPTL4 are angiopoietin-like proteins secreted and expressed mainly by the liver, their role being the regulation of triglyceride metabolism by inhibiting the lipolysis of triglyceride-rich lipoproteins. During different nutritional states (feeding/fasting) the levels of the circulating triglycerides are regulated by Angptl3 and Angptl4 through differential inhibition of Lipoprotein lipase (LPL) as shown by the experimental data. The molecular structure of ANGPTL3 is similar to that of the angiopoietins (vascular endothelial growth factors). Deletion mutants of human Angiopoietin 5 were used in order to demonstrate that the N-terminal domain (fragment 17-207) and not the C-terminal fibrinogen-like domain (fragment 207-460) increased the plasma triglyceride levels in mice. | |
| Physical Appearance | |
| Sterile filtered colorless solution. | |
| Formulation | |
| 1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide. | |
| Applications | |
| ANGPTL3 antibody has been tested by ELISA, Western blot analysis and ICC/IF to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. | |
| Type | |
| Mouse Anti Human Monoclonal. | |
| Clone | |
| PAT23D8AT. | |
| Ig Subclass | |
| Mouse IgG 2a heavy chain and κ light chain. | |
| Purification Method | |
| ANGPTL3 antibody was purified by protein-A affinity chromatography. | |
| Storage Procedures | |
| For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. | |
| Stability / Shelf Life | |
| 12 months at -20°C. 1 month at 4°C. | |
| Precautions | |
| ANGPTL3 (243-460) Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q9Y5C1 ) | |
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ADMEbio Team
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ADMEbio Team
