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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0046-2 | 7 days | 2 µg | $120.00 |
Select product before adding to cart
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| CYK0046-10 | 7 days | 10 µg | $290.00 | |||
| CYK0046-1 | 7 days | 1 mg | $8,320.00 |
Product Overview | |
| Name | APOA5 Human |
|---|---|
| Description | |
| Apolipoprotein A-V Human Recombinant | |
| Accession (Primary) | Q6Q788 |
| Synonyms | |
| Apolipoprotein A-V, Apo-AV, ApoA-V, Apolipoprotein A5, Regeneration-associated protein 3, APOA5, RAP3, APOAV. | |
| Introduction | |
| ApoA5 is an important regulator of serum triglyceride concentrations. An ApoA5 mouse nock-out model produced an approximately four fold increase in serum triglycerides, whereas a knock-in model human ApoA5 produced 50-70% lower concentrations of mouse serum triglycerides. Furthermore, peroxisome proliferators-activated receptoragonists, which are used clinically to lower serum triglyceride concentrations, cause increased ApoA5 mRNA expression. There is very little known about ApoA5 protein in human serum. Lately, it was established that ApoA5 is present in the human serum and it can be detected by polyclonal antibodies against both the HN2 and COOH termini, but at much lower concentration than other apolipoproteins. | |
| Source | |
| HEK293 | |
| Physical Appearance | |
| Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| APOA5 Human was filtered (0.4 µm) and lyophilized from 0.5 mg/ml supplied in 20mM TRIS and 50mM NaCl, pH 7.5 | |
| Stability | |
| Store lyophilized APOA5 Human at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted APOA5 Human can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. | |
| Purity | |
| Greater than 90% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| RKGFWDYFSQ TSGDKGRVEQ IHQQKMAREP ATLKDSLEQD LNNMNKFLEK LRPLSGSEAP RLPQDPVGMR RQLQEELEEV KARLQPYMAE AHELVGWNLE GLRQQLKPYT MDLMEQVALR VQELQEQLRV VGEDTKAQLL GGVDEAWALL QGLQSRVVHH TGRFKELFHP YAESLVSGIG RHVQELHRSV APHAPASPAR LSRCVQVLSR KLTLKAKALH ARIQQNLDQL REELSRAFAG TGTEEGAGPD PQMLSEEVRQ RLQAFRQDTY LQIAAFTRAI DQETEEVQQQ LAPPPPGHSA FAPEFQQTDS GKVLSKLQAR LDDLWEDITH SLHDQGHSHL GDP AAADYKD DDDK | |
| Solubility | |
| It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it on cell culture. | |
| Precautions | |
| APOA5 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q6Q788 ) | |
Background |
Apolipoprotein A-V Human Recombinant: Unleashing the Power of Lipid Regulation Abstract: Apolipoprotein A-V (ApoA-V), a fascinating player in the intricate world of lipid metabolism, has emerged as a promising therapeutic target for lipid disorders. Produced primarily in the liver, ApoA-V exerts a profound influence on triglyceride metabolism. Dysregulation of ApoA-V has been implicated in various lipid-related disorders, including hypertriglyceridemia and cardiovascular diseases (CVDs). This research paper offers a concise yet comprehensive exploration of ApoA-V human recombinant, shedding light on its physiological functions, production methods, and potential therapeutic applications. Introduction: In the face of the soaring global burden of lipid disorders and cardiovascular ailments, novel therapeutic approaches are urgently needed. Apolipoproteins, the guardians of lipid transport, present promising targets for intervention. Among them, ApoA-V, a master regulator of triglyceride metabolism, holds great promise. Structure and Function of Apolipoprotein A-V: ApoA-V boasts an elegant molecular architecture, comprising specific domains that enable its interaction with lipoproteins engaged in lipid transport. Through its intricate mechanisms, ApoA-V fine-tunes triglyceride levels by modulating lipoprotein lipase activity and enhancing the clearance of triglyceride-rich lipoproteins. Genetic Variations and Lipid Disorders: Exploring the fascinating realm of genetics has uncovered ApoA-V gene polymorphisms linked to dyslipidemia, including hypertriglyceridemia. These genetic variations influence ApoA-V expression and function, thereby contributing to the development of lipid disorders and heightened cardiovascular risk. Production of Apolipoprotein A-V Human Recombinant: Harnessing the power of biotechnology, scientists have devised various expression systems, encompassing mammalian cells and bacteria, to produce recombinant ApoA-V. These techniques enable large-scale production, purification, and meticulous characterization of the recombinant protein, opening doors to potential therapeutic applications. Therapeutic Applications of Apolipoprotein A-V Human Recombinant: The prospect of targeting ApoA-V beckons as a promising avenue for managing lipid disorders, particularly hypertriglyceridemia. By manipulating ApoA-V expression or function, it becomes possible to reduce triglyceride levels, improve lipid profiles, and mitigate the risk of cardiovascular complications. Conclusion: Apolipoprotein A-V human recombinant represents a beacon of hope in the quest to conquer lipid disorders. Understanding the intricate interplay between ApoA-V's structure, function, and genetic variations offers profound insights into its potential role in personalized medicine. Unleashing the full therapeutic potential of ApoA-V human recombinant requires further scientific exploration and clinical studies, paving the way for effective interventions in lipid-related disorders. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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ADMEbio Team
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ADMEbio Team
