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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0068-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
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| CYK0068-20 | 7 days | 20 µg | $290.00 | |||
| CYK0068-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | BD 1 Mouse |
|---|---|
| Description | |
| BD 1 Mouse | |
| Accession (Primary) | P56386 |
| Synonyms | |
| Beta-defensin 1, BD-1, rBD-1, Defensin beta 1, Defb1. | |
| Introduction | |
| The Defensin family are highly similar in their protein sequence and are microbicidal & cytotoxic peptides made by neutrophils. Beta Defensin-1 is an antimicrobial peptide having the resistance of epithelial surfaces to microbial colonization. Beta Defensin-1 has close proximity to Defensin Alpha-1 and has been implicated in the pathogenesis of cystic fibrosis. Skin of patients having atopic dermatitis patients and mycosis fungoides (non-lesional and lesional) show lower human Beta Defensin-1 mRNA expression and higher human Beta Defensin-2 and human Beta Defensin-3 mRNA expression. Beta Defensin is highly expressed by epithelial cells. Beta-defensin 1 may play a role in the pathogenesis of severe sepsis. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| BD-1 protein was lyophilized from a 0.2 µm filtered concentrated solution in PBS, pH 7.4. | |
| Stability | |
| Lyophilized BD-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BD-1 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| DQYRCLQNGG FCLRSSCPSH TKLQGTCKPD KPNCCRS. | |
| Biological Activity | |
| Measured by its ability to chemoattract CD34+ dendritic cells using a concentration range of 0.1-1.0 ug/ml. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized BD-1 in sterile 18M-cm H 2 O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| BD 1 Mouse is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P56386 ) | |
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ADMEbio Team
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ADMEbio Team
