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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0080-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
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| CYK0080-20 | 7 days | 20 µg | $290.00 | |||
| CYK0080-1 | 7 days | 1 mg | $3,360.00 |
Product Overview | |
| Name | BMP 2 Human, Monomer |
|---|---|
| Description | |
| Bone Morphogenetic Protein-2 Human Recombinant, Monomer | |
| Accession (Primary) | P12643 |
| Synonyms | |
| BMP-2, BMP2A. | |
| Introduction | |
| BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein induces bone formation. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| BMP2 was lyophilized from a concentrated (1mg/ml) sterile solution containing 10mM sodium citrate pH=3.5. | |
| Stability | |
| Lyophilized Bone Morphogenetic Protein-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BMP2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR. | |
| Biological Activity | |
| The ED 50 as determined by its ability to induce alkaline phosphatase production by ATDC-5 cells is 0.5-1.0 µg/ml. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Bone Morphogenetic Protein-2 in sterile 20mM AcOH (acetic Acid) not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| References | |
| Title :β-Catenin Signaling Pathway Is Crucial for Bone Morphogenetic Protein 2 to Induce New Bone Formation. Publication :First Published on November 3, 2006, doi: 10.1074/jbc.M602700200 January 5, 2007 The Journal of Biological Chemistry, 282, 526-533. Link : BMP 2 prospec publication | |
| Protein content | |
| Protein quantitation was carried out by two independent methods: 1. UV spectroscopy at 280 nm using the absorbency value of 1.4 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2. Analysis by RP-HPLC, using a standard solution of BMP-2 as a Reference Standard. | |
| Precautions | |
| BMP 2 Human, Monomer is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P12643 ) | |
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