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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0090-2 | 7 days | 2 µg | $120.00 |
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| CYK0090-10 | 7 days | 10 µg | $290.00 | |||
| CYK0090-100 | 7 days | 100 µg | $1,600.00 |
Product Overview | |
| Name | BMP4 Human, Active |
|---|---|
| Description | |
| Bone Morphogenetic protein-4 Active Active, Human Recombinant | |
| Accession (Primary) | P12644 |
| Synonyms | |
| BMP4, ZYME, BMP2B, BMP2B1. | |
| Introduction | |
| The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. | |
| Source | |
| CHO cells. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The protein was lyophilized from a sterile (0.2 µm) filtered solution containing 0.1% Trifluoroacetic Acid (TFA). | |
| Stability | |
| Lyophilized BMP4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BMP4 should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| SPKHHSQRAR KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAI VQT LVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR. | |
| Biological Activity | |
| The ED 50 , as calculated by Alkaline phosphatase activity induced in ATDC-5 cells is 15ng/ml corresponding to a specific activity which is 6.7 x 10^4 units/mg. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized BMP4 in sterile 10mM HCl at a concentration of 0.1 mg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| BMP4 Human, Active is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P12644 ) | |
Background |
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. |
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