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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0116-2 | 7 days | 2 µg | $120.00 |
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| CYK0116-10 | 7 days | 10 µg | $290.00 | |||
| CYK0116-1 | 7 days | 1 mg | $5,760.00 |
Product Overview | |
| Name | Clusterin Rat |
|---|---|
| Description | |
| Clusterin Rat Recombinant | |
| Accession (Primary) | P05371 |
| Immunogen | |
| Anti-human CMBL mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CMBL 1-245 amino acids purified from E. coli. | |
| Synonyms | |
| Carboxymethylenebutenolidase homolog, CMBL, JS-1. | |
| Introduction | |
| Carboxymethylenebutenolidase homolog (CMBL) is a cysteine hydrolase of the dienelactone hydrolase family which is highly expressed in the liver cytosol. CMBL is the human homolog of Pseudomonas dienelactone hydrolase, which is a protein that participates in the bacterial halocatechol degradation pathway. CMBL which preferentially cleaves cyclic esters activates medoxomil-ester prodrugs in which the medoxomil moiety is coupled with an oxygen atom. CMBL is inhibited by PCMB (p-chloromercuribenzoate) and is encoded by a gene which maps to human chromosome 5p15.2. Furthermore, CMBL converts the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, which is an angiotensin receptor blocker, in the liver and intestine. CMBL can also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. CMBL is widely expressed, with the highest levels in the liver, followed by the kidney, small intestine and the colon. | |
| Physical Appearance | |
| Sterile Filtered colorless solution. | |
| Formulation | |
| 1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide. | |
| Applications | |
| CMBL antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1:5000. Recommended starting dilution is 1:500. | |
| Type | |
| Mouse Anti Human Monoclonal. | |
| Clone | |
| PAT2B11AT. | |
| Ig Subclass | |
| Mouse IgG2a heavy chain and lambda light chain. | |
| Purification Method | |
| CMBL antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. | |
| Storage Procedures | |
| For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. | |
| Stability / Shelf Life | |
| 12 months at -20°C. 1 month at 4°C. | |
| Precautions | |
| Clusterin Rat is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P05371 ) | |
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ADMEbio Team
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ADMEbio Team
