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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0132-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
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| CYK0132-25 | 7 days | 25 µg | $290.00 | |||
| CYK0132-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | DHH (C23II) Mouse |
|---|---|
| Description | |
| Desert Hedgehog (C23II) Mouse Recombinant | |
| Accession (Primary) | Q61488 |
| Synonyms | |
| HHG-3, Desert Hedgehog homolog, MGC35145, Desert hedgehog protein, DHH. | |
| Introduction | |
| DHH is part of the Hedgehog family which encodes signaling molecules that are involved in regulating morphogenesis. DHH protein is a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. Additionally, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in DHH protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. DHH plays a role both male gonadal differentiation and perineurial development. DHH plays a role in intercellular signaling which is essential for a variety of patterning events during development. DHH functions as a spermatocyte survival factor in the testes & is essential for testes development. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile filtered colorless solution. | |
| Formulation | |
| DHH solution containing 20mM MES pH-5.5, 0.5mM DTT and 20% glycerol. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| MGSSHHHHHH SSGLVPRGSH MCGPGRGPVG RRRYARKQLV PLLYKQFVPG VPERTLGASG PAEGRVARGS ERFRDLVPNY NPDIIFKDEE NSGADRLMTE RCKERVNALA IAVMNMWPGV RLRVTEGWDE DGHHAQDSLH YEGRALDITT SDRDRNKYGL LARLAVEAGF DWVYYESRNH VHVSVKADNS LAVRAGG. | |
| Precautions | |
| DHH (C23II) Mouse is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q61488 ) | |
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ADMEbio Team
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