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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0150-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
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| CYK0150-20 | 7 days | 20 µg | $290.00 | |||
| CYK0150-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | FASLG Human |
|---|---|
| Description | |
| FAS Ligand Human Recombinant | |
| Accession (Primary) | P48023 |
| Synonyms | |
| Fas ligand (TNF superfamily, member 6), APT1LG1, FASL, TNFSF6, CD178, tumor necrosis factor (ligand) superfamily member 6, Apoptosis antigen ligand, Fas antigen ligand, APTL, CD95-L. | |
| Introduction | |
| The type II transmembrane protein FASLG is a member of the tumor necrosis factor (TNF) superfamily. A fas ligand/receptor interaction has a significant part in the regulation of the immune system and the advancement of cancer. FASLG is expressed on the activated T cell surface as a nondisulfidelinked homotrimer. FASLG binding to Fas/CD95/TNFRSF6 on a nearby cell prompts apoptosis in the Fas expressing cell. FASLG is released from the cell surface by metalloproteinases as a soluble molecule that stays trimeric and is able to bind with Fas, but its capability to activate apoptosis is radically reduced. In addition, FASLG binds to DcR3 - a soluble trap receptor with no signal transduction capabilities. Flawed Fas-mediated apoptosis causes oncogenesis in addition to drug resistance in existing tumors. Constitutive expression of FASLG in a variety of tumors enables their immune evasion. Both mouse and human FASLG are active on mouse and human cells. | |
| Source | |
| HEK293 cells. | |
| Physical Appearance | |
| Sterile Filtered colorless solution. | |
| Formulation | |
| The FASLG solution (0.6mg/ml) contains 1xPBS. | |
| Stability | |
| FASLG Human Recombinant although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by: (a) Analysis by SEC-HPLC. (b) Analysis by SDS-PAGE. | |
| Biological Activity | |
| Fas ligand is biologically active as determined by its ability to induce cytotoxicity in Jurkat cells in the absence of any cross-linking. The expected ED 50 < 10 ng/ml, corresponding to a specific activity of 1x10 5 units/mg. | |
| Precautions | |
| FASLG Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P48023 ) | |
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ADMEbio Team
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ADMEbio Team
