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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0152-2 | 7 days | 2 µg | $120.00 |
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| CYK0152-10 | 7 days | 10 µg | $290.00 | |||
| CYK0152-1 | 7 days | 1 mg | $5,616.00 |
Product Overview | |
| Name | Flt3 Ligand Human |
|---|---|
| Description | |
| Flt3 Ligand Human Recombinant | |
| Accession (Primary) | P49771 |
| Synonyms | |
| Fms-related tyrosine kinase 3 ligand, FLK2, STK1, CD135, Stem Cell Tyrosine Kinase 1, FLT3LG, Flt3. | |
| Introduction | |
| FLT3 ligand is a receptor for the fl cytokine has a tyrosine-protein kinase activity & a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand synergizes with other CSFs and interleukins to induce growth and differentiation. | |
| Source | |
| HEK293 (Human Embryonic Kidney cell line). | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Flt3-Ligand was lyophilized from a 0.2 µm filtered solution containing 1xPBS. | |
| Stability | |
| Lyophilized Flt3-Ligand although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Flt3-Ligand should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| TQDCSFQHSP ISSDFAVKIR ELSDYLLQDY PVTVASNLQD EELCGGLWRL VLAQRWMERL KTVAGSKMQG LLERVNTEIH FVTKCAFQPP PSCLRFVQTN ISRLLQETSE QLVALKPWIT RQNFSRCLEL QCQPDSSTLP PPWSPRPLEA TAPTAPQP. | |
| Biological Activity | |
| The activity was determined by the dose- dependent stimulation of the proliferation of the human acute myeloid leukemia cell line OCI-AML5. The ED 50 is 0.56ng/ml. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Flt3-Ligand in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| Flt3 Ligand Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P49771 ) | |
References |
1. Title :Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2. Publication :Published online before printMay 9, 2006, doi:10.1182/blood-2005-07-008896 Submitted: July 14, 2005Accepted: April 26, 2006 Blood September 1 , 2006vol. 108no. 51542-1550. Link : Flt3 Ligand prospec publication 2. Title :A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival. Publication :Received 2 February 2009; accepted for publication 30 March 2009 Correspondence: Lars Ro¨nnstrand,Experimental Clinical Chemistry, WallenbergLaboratory, Entr. 46, 5th fl, Malmo¨ University Hospital, SE-20502 Malmo¨, Sweden.E-mail: lars.ronnstrand@med.lu.se;http://www.expklkemi.mas.lu.se Link : Flt3 Ligand Human prospec publication |
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