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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0164-2 | 7 days | 2 µg | $120.00 |
Select product before adding to cart
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| CYK0164-10 | 7 days | 10 µg | $290.00 | |||
| CYK0164-1 | 7 days | 1 mg | $8,320.00 |
Product Overview | |
| Name | FSTL1 Human, HEK |
|---|---|
| Description | |
| Follistatin Like 1 Human Recombinant, HEK | |
| Accession (Primary) | Q12841 |
| Synonyms | |
| Formiminotransferase-cyclodeaminase, FTCD, LCHC1, LC-1. | |
| Introduction | |
| Formiminotransferase cyclodeaminase is an enzyme which catalyzes the conversion of formiminoglutamateand tetrahydrofolateinto formiminotetrahydrofolateand glutamate. Formiminotransferase cyclodeaminase, a bifunctional enzyme of tetrahydrofolate synthesis, is the target antigen of anti-LC1 (liver cytosol antigen type 1) autoantibodies. Presence of LC1 autoantibodies is a marker for type 2 autoimmune hepatitis (for which anti-LKM 1/cytochrome P450 2D6 autoantibodies are a further marker). Serum LC1 autoantibody concentrations appear to fluctuate in parallel with aminotransferase levels, a particularly intriguing observation that suggests a possible role of LC1 autoreactivity in the pathogenic mechanism leading to hepatocyte injury. | |
| Source | |
| Sf9 insect cells. | |
| Formulation | |
| FTCD is supplied in 16mM HEPES buffer pH-7.6, 240mM sodium chloride, and 20% glycerol. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°Cfor longer periods of time. Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 95% as determined by SDS-PAGE. | |
| Immunological functions | |
| 1. Binds IgG-type human auto-antibodies. 2. Standard ELISA test (checker-board analysis of positive/negative sera panels, immuno-dot test). | |
| Coating concentration | |
| 0.35-0.7 µg/ml (depending on the type of ELISA plate and coating buffer). Suitable for biotinylation and iodination. | |
| Precautions | |
| FSTL1 Human, HEK is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q12841 ) | |
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ADMEbio Team
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ADMEbio Team
