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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0176-10 | 7 days | 10 µg | $120.00 |
Select product before adding to cart
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| CYK0176-50 | 7 days | 50 µg | $290.00 | |||
| CYK0176-1 | 7 days | 1 mg | $2,160.00 |
Product Overview | |
| Name | GDF5 Human |
|---|---|
| Description | |
| Growth Differentiation Factor-5 Human Recombinant | |
| Accession (Primary) | P43026 |
| Synonyms | |
| Cartilage-derived morphogenetic protein-1, CDMP-1, LAP4, SYNS2, GDF-5, Radotermin, CDMP1, GDF5, Growth differentiation factor 5, BMP-14. | |
| Introduction | |
| GDF-5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered colorless solution. | |
| Formulation | |
| The GDF5 solution contains 10mM sodium citrate pH-3.5 and 10% glycerol. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| MGSSHHHHHH SSGLVPRGSH MAPLATRQGK RPSKNLKARC SRKALHVNFK DMGWDDWIIA PLEYEAFHCE GLCEFPLRSH LEPTNHAVIQ TLMNSMDPES TPPTCCVPTR LSPISILFID SANNVVYKQY EDMVVESCGC R. | |
| Precautions | |
| GDF5 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P43026 ) | |
References |
Title :Growth/differentiation Factor-5 Induces Osteogenic Differentiation of Human Ligamentum Flavum Cells through Activation of ERK1/2 and p38 MAPK. Publication : Cell Physiol Biochem 2010;26:179-186 (DOI: 10.1159/000320526) Link : GDF5 prospec publication |
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