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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0177-5 | 7 days | 5 µg | $120.00 |
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| CYK0177-25 | 7 days | 25 µg | $290.00 | |||
| CYK0177-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | GDF5 Human, His |
|---|---|
| Description | |
| Growth differentiation factor 5 Human Recombinant, His Tag | |
| Accession (Primary) | P43026 |
| Synonyms | |
| Bmp-14, Bp, GDF-5, Bone morphogenetic protein 14, GDF5, Growth/differentiation factor 5. | |
| Introduction | |
| GDF-5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| GDF-5 protein was lyophilized from a 0.2 µm filtered concentrated solution in 30% Acetonitrile and 0.1% TFA. | |
| Stability | |
| Lyophilized GDF5 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GDF-5 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 96.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| APLANRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR. | |
| Biological Activity | |
| The ED 50 as determined by inducing alkaline phosphatase production of murine ATDC5 cells is less than 1.0 µg/ml, corresponding to a specific activity of > 1000IU/mg. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized GDF5 in sterile 4mM HCl not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| GDF5 Human, His is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P43026 ) | |
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ADMEbio Team
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ADMEbio Team
