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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0180-2 | 7 days | 2 µg | $120.00 |
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| CYK0180-10 | 7 days | 10 µg | $290.00 | |||
| CYK0180-1 | 7 days | 1 mg | $7,488.00 |
Product Overview | |
| Name | GDF7 Human |
|---|---|
| Description | |
| Growth and Differentiation factor 7 Human Recombinant | |
| Accession (Primary) | Q7Z4P5 |
| Synonyms | |
| Growth/differentiation factor 7, GDF-7, Gdf7. | |
| Introduction | |
| Growth Differentiation Factor-7 (GDF-7) belongs to the BMP family of TGF-b superfamily proteins. GDF7 elicits its bioactivity via a heterodimeric receptor complex comprised of a type 1 (BMPR-IB) and a type II (BMPR-II or Activin RII) serine/threonine kinase receptor. GDF7 signaling results in the phosphorylation and activation of Smad proteins. GDF-7 is also involved in tendon and ligament formation and repair. In addition, GDF7 regulates bone formation, mesenchymal stem cell differentiation, neuronal differentiation, and axon guidance. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| GDF7 protein was lyophilized from a 0.2 µm filtered concentrated solution in 30% Acetonitrile and 0.1% TFA. | |
| Stability | |
| Lyophilized GDF7 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GDF-7 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| TALAGTRGAQ GSGGGGGGGG GGGGGGGGGG GGAGRGHGRR GRSRCSRKSL HVDFKELGWD DWIIAPLDYE AYHCEGVCDF PLRSHLEPTN HAIIQTLLNS MAPDAAPASC CVPARLSPIS ILYIDAANNV VYKQYEDMVV EACGCR. | |
| Biological Activity | |
| The ED 50 as determined by inducing alkaline phosphatase production of murine ATDC5 cells is less than 0.5 µg/ml, corresponding to a specific activity of > 2000 IU/mg. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized GDF-7 in sterile 18M-cm H 2 O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| GDF7 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q7Z4P5 ) | |
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ADMEbio Team
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