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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0186-20 | 7 days | 20 µg | $120.00 |
Select product before adding to cart
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| CYK0186-100 | 7 days | 100 µg | $290.00 | |||
| CYK0186-1 | 7 days | 1 mg | $1,440.00 |
Product Overview | |
| Name | IFN a 2a Human |
|---|---|
| Description | |
| IFN-Alpha 2a Human Recombinant | |
| Accession (Primary) | P01563 |
| Synonyms | |
| Leukocyte interferon, B cell interferon, Type I interferon, IFNA2, IFN-a 2a. | |
| Introduction | |
| IFN-alpha is produced by macrophages and has antiviral activities. Interferon stimulates the production of two enzymes: protein kinase and an oligoadenylate synthetase. | |
| Source | |
| Nicotiana Sp.Plant. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Lyophilized, containing 50% SDS. | |
| Stability | |
| Lyophilized Interferon alpha 2a although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IFN-alpha 2a should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 99.0% as determined by both: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| The sequence of the first twelve N-terminal amino acids was determined and was found to be Cys-Asp-Leu-Pro-Gln-Thr-His-Ser-Leu-Gly-Ser-Arg. | |
| Biological Activity | |
| The specific activity was determined by a quantitative gene report bioassay using human Type I interferon-sensitive cells. Compared with bacterial derived recombinant IFN-a 2a, assayed in the same conditions, plant derived IFN-alpha 2a showed 6.1 × 10 8 Units/mg in reference to a viral resistance assay using bovine kidney MDBK cells. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Interferon-alpha 2a in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| IFN a 2a Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P01563 ) | |
References |
1. Title :Gender specificity of altered human immune cytokine profiles in aging. Publication :Published online before print May 7, 2010, doi: 10.1096/fj.10-160911 September 2010 The FASEB Journal vol. 24 no. 9 3580-3589 Link: IFN a 2a prospec publication 2. Title: Differential involvement of 5-HT1A and 5-HT1B/1D receptor in human IFN a-induced immobility Publication: Arzneimittel-Forschung 60.3 (2009): 109-115. Link: IFN-Alpha 2a prospec publication |
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