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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0251-2 | 7 days | 2 µg | $120.00 |
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| CYK0251-10 | 7 days | 10 µg | $290.00 | |||
| CYK0251-1 | 7 days | 1 mg | $7,488.00 |
Product Overview | |
| Name | IL 13 Rat 109 a.a. |
|---|---|
| Description | |
| Interleukin-13 109 a.a. Rat Recombinant | |
| Accession (Primary) | P42203 |
| Synonyms | |
| NC30, ALRH, BHR1, P600, IL-13, MGC116786, MGC116788, MGC116789. | |
| Introduction | |
| IL13 is an immunoregulatory cytokine produced primarily by activated Th2 cells. IL-13 is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Lyophilized from a 0.2?m filtered concentrated solution in PBS, pH 7.4 containing 5% trehalose. | |
| Stability | |
| Lyophilized IL-13 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL-13 should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 97.0% as determined by SDS-PAGE and HPLC analyses. | |
| Amino acid sequence | |
| SPSPVPRSTA LKELIEELVN ITQNQKAPLC NGSMVWSINL TAGVYCAALE SLINVSGCSA IEKTQRMLNG FCPHKVSAGQ FSSLRVRDTK IEVAQFVKDL LVHLKKLFRE GRFN | |
| Biological Activity | |
| The ED50 as determined by the dose-dependent proliferation of TF-1 cells was < 1.0 ng/ml, corresponding to a specific activity of > 1×1,000,000 units/mg. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized IL-13 in sterile 18M-cm H 2 O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| IL 13 Rat 109 a.a. is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P42203 ) | |
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ADMEbio Team
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