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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0269-2 | 7 days | 2 µg | $120.00 |
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| CYK0269-10 | 7 days | 10 µg | $290.00 | |||
| CYK0269-0.1 | 7 days | 0.1 mg | $1,440.00 |
Product Overview | |
| Name | IL 17A/F Rat |
|---|---|
| Description | |
| Interleukin-17A/F Heterodimer Rat Recombinant | |
| Synonyms | |
| Interleukin-17B, IL-17B, Cytokine Zcyto7, Interleukin-20, Neuronal interleukin-17-related factor, IL20, NIRF, ZCYTO7. | |
| Introduction | |
| IL-17 family members are glycoproteins secreted as dimers which induce local cytokine production and recruit granulocytes to sites of inflammation. The IL-17 family is comprised of at least six pro-inflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 is induced by IL-15 and IL-23, mostly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL17B Diseases associated with IL17B include spondyloarthropathy, and neuronitis, and among its related super-pathways are Mucin expression in CF via IL-6, IL-17 signaling pathways and STAT3 Pathway. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Interleukin-17B was Lyophilized from a 0.2 µm filtered concentrated solution in PBS, pH7.4, 0.05% Tween-20 and 3%Trehalose. | |
| Stability | |
| Lyophilized Interleukin 17B although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution IL17B should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| MQPRSPKSKR KGQGRPGPLA PGPHQVPLDL VSRMKPYARM EEYERNIEEM VAQLRNSSEL AQRKCEVNLQ LWMSNKRSLS PWGYSINHDP SRIPVDLPEA RCLCLGCVNP FTMQEDRSMV SVPVFSQVPV RRRLCPPPPR TGPCRQRAVM ETIAVGCTCI F. | |
| Biological Activity | |
| The ED50 as determined by inducing IL-8 secretion of human HepG2 cells is less than 1.0 µg/ml, corresponding to a specific activity of > 1000 IU/mg. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Interleukin 17B in sterile 18M-cm H 2 O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| IL 17A/F Rat is for research use only and not for use in diagnostic or therapeutic procedures. | |
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