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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0277-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
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| CYK0277-25 | 7 days | 25 µg | $290.00 | |||
| CYK0277-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | IL 18 Mouse, His |
|---|---|
| Description | |
| Interleukin-18 Mouse Recombinant, His Tag | |
| Accession (Primary) | P70380 |
| Synonyms | |
| Melanoma differentiation association like protein, MDA1, NG.1, ZMDA1, IL-10C, IL-19. | |
| Introduction | |
| IL19 is a cytokine that belongs to the IL10 cytokine subfamily. IL-19 is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Lyophilized from a concentrated (1mg/ml) solution in water containing 10mM sodium citrate pH-5. | |
| Stability | |
| Lyophilized Interleukin-19 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL19 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 99.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| The sequence of the first five N-terminal amino acids was determined and was found to be Met-Leu-Arg-Arg-Cys. | |
| Biological Activity | |
| The activity is determined by it's ability to activate STAT following receptor-ligand interaction. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Interleukin -19 in sterile 18MΩ-cm H2O at a concentration of 0.5mg/ml or less. | |
| Precautions | |
| IL 18 Mouse, His is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P70380 ) | |
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ADMEbio Team
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