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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0282-10 | 7 days | 10 µg | $300.00 |
Select product before adding to cart
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| CYK0282-50 | 7 days | 50 µg | $1,000.00 | |||
| CYK0282-1 | 7 days | 1 mg | $8,320.00 |
Product Overview | |
| Name | IL 1RA Human His |
|---|---|
| Description | |
| Interleukin-1 Receptor Antagonist Human Recombinant, His Tag | |
| Accession (Primary) | P18510 |
| Synonyms | |
| IRAP, IL1F3, IL1RA, IL-1ra3, ICIL-1RA, IL1RN, IL1 inhibitor, IL-1ra, F630041P17Rik. | |
| Introduction | |
| Interleukin-1 ra is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The protein was lyophilized from a concentrated (1mg/ml) solution in water containing NaHCO3. | |
| Stability | |
| Lyophilized Interleukin 1ra although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL-1ra should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 98.0% as determined by: (a) Analysis by Gel Filtration. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| The sequence of the first six N-terminal amino acids was determined and was found to be Ala-Cys-Arg-Pro-Ser-Gly. | |
| Biological Activity | |
| The mouse IL-1Ra is capable of inhibiting IL-1-alpha activity in helper T cell line D10.G4.1. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Interleukin-1ra in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Protein content | |
| Protein quantitation was carried out by two independent methods: 1. UV spectroscopy at 280 nm using the absorbency value of 0.91 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2. Analysis by RP-HPLC, using a standard solution of IL-1 ra as a Reference Standard. | |
| Precautions | |
| IL 1RA Human His is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P18510 ) | |
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ADMEbio Team
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